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1

Safety Pharmacology assessment of drugs with biased 5-HT2B receptor agonism mediating cardiac valvulopathy

Cavero, Icilio, Guillon, Jean-Michel

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2014

Language:

english

File:

PDF, 748 KB

english, 2014

2

ICH S7B draft guideline on the non-clinical strategy for testing delayed cardiac repolarisation risk of drugs: a critical analysis

Cavero, Icilio, Crumb, William

Journal:

Expert Opinion on Drug Safety

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

3

The development of glutamate-based antidepressants is taking longer than expected

Garay, Ricardo, Zarate, Carlos A., Cavero, Icilio, Kim, Yong-Ku, Charpeaud, Thomas, Skolnick, Phil

Journal:

Drug Discovery Today

Year:

2018

Language:

english

File:

PDF, 628 KB

english, 2018

4

Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates

Cavero, Icilio, Guillon, Jean-Michel, Holzgrefe, Henry H

Journal:

Expert Opinion on Drug Safety

Year:

2019

Language:

english

File:

PDF, 2.26 MB

english, 2019

5

Inhibition of central pressor effects of angiotensin I and II

Thomas A. Solomon, Icilio Cavero, Joseph P. Buckley

Journal:

Journal of Pharmaceutical Sciences

Year:

1974

Language:

english

File:

PDF, 459 KB

english, 1974

6

Ischemic myocardial cell protection conferred by the opening of ATP-sensitive potassium channels

Icilio Cavero, Yasmine Djellas, Jean-Michel Guillon

Journal:

Cardiovascular Drugs and Therapy

Year:

1995

Language:

english

File:

PDF, 1.20 MB

english, 1995

7

Frequency-independent blockade of cardiac Na+channels by riluzole: comparison with established anticonvulsants and class I anti-arrhythmics

Michel Mestre, Yasmine Djellas, Thierry Carriot, Icilio Cavero

Journal:

Fundamental & Clinical Pharmacology

Year:

2000

Language:

english

File:

PDF, 918 KB

english, 2000

8

Validation of a novel technique allowing assessment of the functional role of cardiac prejunctional receptors in the rat

Icilio Cavero, Chantal Thiry

Journal:

Autonomic and Autacoid Pharmacology

Year:

1990

Language:

english

File:

PDF, 612 KB

english, 1990

9

2011 Annual Meeting of the Safety Pharmacology Society: an overview

Journal:

Expert Opinion on Drug Safety

Year:

2012

Language:

english

File:

PDF, 314 KB

english, 2012

10

Synthesis and antihypertensive activity of a series of 4-amino-6,7-dimethoxyquinazoline derivatives

Binet, Jean L., Dumas, Andre P., Lefevre-Borg, Francoise, Cavero, Icilio, Manoury, Philippe M.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 898 KB

english, 1986

11

Simple-to-use, reference criteria for revealing drug-induced QT interval prolongation in conscious dogs

Michael W. Schmitt, Friedrich Von Landenberg, Hartmut Poth, Elmar Wimmer, Thomas Goddemeier, Icilio Cavero

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 317 KB

english, 2007

12

Safety pharmacology and prolongation of the QT interval

Icilio Cavero, Gan-Xin Yan, Robert Lux, Uwe Steinhoff

Journal:

Journal of Electrocardiology

Year:

2007

Language:

english

File:

PDF, 112 KB

english, 2007

13

Novel probabilistic method for precisely correcting the QT interval for heart rate in telemetered dogs and cynomolgus monkeys

Henry H. Holzgrefe, Icilio Cavero, Carol R. Gleason, William A. Warner, Lewis V. Buchanan, Michael W. Gill, Dennis E. Burkett, Stephen K. Durham

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 667 KB

english, 2007

14

Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: Effects of moxifloxacin

Henry H. Holzgrefe, Icilio Cavero, Lewis V. Buchanan, Michael W. Gill, Stephen K. Durham

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 799 KB

english, 2007

15

Analysis of the nonclinical telemetered ECG: Impact of logging rate and RR bin width in the dog and cynomolgus monkey

Henry H. Holzgrefe, Icilio Cavero, Carol R. Gleason

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 365 KB

english, 2007

16

Avoiding adverse modification of cardiac repolarization

Icilio Cavero, Rob Towart

Journal:

Pharmaceutical Science & Technology Today

Year:

2000

Language:

english

File:

PDF, 43 KB

english, 2000

17

QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development

William Crumb, Icilio Cavero

Journal:

Pharmaceutical Science & Technology Today

Year:

1999

Language:

english

File:

PDF, 293 KB

english, 1999

18

Synthesis of a series of compounds related to betaxolol, a new .beta.1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases

Manoury, Philippe M., Binet, Jean L., Rousseau, Jean, Lefevre-Borg, Francoise M., Cavero, Icilio G.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.26 MB

english, 1987

19

The Myocardial Lesions Produced by the Potassium Channel Opener Aprikalim in Monkeys and Rats Are Prevented by Blockade of Cardiac β-Adrenoceptors

Vincent Belin, Thomas Hodge, Philippe Picaut, Roy Jordan, Carol Algate, Sylvie Gosselin, Gerhard Nohynek, Icilio Cavero

Journal:

Fundamental and Applied Toxicology

Year:

1996

Language:

english

File:

PDF, 2.19 MB

english, 1996

20

The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes

Denis Escande, Dominique Thuringer, Sylvain Leguern, Icilio Cavero

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 367 KB

english, 1988

21

Paf binding sites: Characterization by [3h]52770 rp, a pyrrolo[1,2-c]thiazole derivative, in rabbit platelets

Christine Robaut, Gabrielle Durand, Claude James, Daniel Lave, Pierre Sedivy, Anne Floch, Serge Mondot, Daniel Pacot, Icilio Cavero, Gérard Le Fur

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 1017 KB

english, 1987

22

Blocking platelet activating factor receptors with RP 59227 decreases myocardial infarct size and the incidence of ventricular fibrillation

John A Auchampach, Masahiko Maruyama, Icilio Cavero, Garrett J Gross

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1991

Language:

english

File:

PDF, 108 KB

english, 1991

23

Trophoblastic localization of [125I] endothelin-1binding sites in human placenta

André Malassiné, Françoise Mondon, Christine Robaut, Micheline Vial, Josette Bandet, Gisèle Tanguy, William Rostène, Icilio Cavero, Françoise Ferré

Journal:

Year:

1993

Language:

english

File:

PDF, 2.93 MB

english, 1993

24

EFFECTS OF MIANSERIN, DESIPRAMINE AND MAPROTILINE ON BLOOD PRESSURE RESPONSES EVOKED BY ACETYLCHOLINE, HISTAMINE AND 5-HYDROXYTRYPTAMINE IN RATS

ICILIO CAVERO, FRANÇOISE LEFÈVRE-BORG, ALAN G. ROACH

Journal:

British Journal of Pharmacology

Year:

1981

Language:

english

File:

PDF, 802 KB

english, 1981

25

Contractile responses to calcium chloride in rat aortic rings bathed in K+-free solution are resistant to organic calcium antagonists

Kim Lawson, Icilio Cavero

Journal:

British Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 738 KB

english, 1989

26

Influence of plasma protein content and platelet number on the potency of PAF and its antagonist RP 59227 in rabbit platelet preparations

Anne Floch, Icilio Cavero

Journal:

British Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 950 KB

english, 1990

27

Cross tachyphylaxis to endothelin isopeptide-induced hypotension: a phenomenon not seen with proendothelin

Anne-Charlotte Le Monnier de Gouville, Icilio Cavero

Journal:

British Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.50 MB

english, 1991

28

Characterization of NK1 and NK2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systems

Anne Floch, Véronique Fardin, Icilio Cavero

Journal:

British Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 2.05 MB

english, 1994

29

Effects of β2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways

Isabelle Gorenne, Carlos Labat, Xavier Norel, Vincent De Montpreville, Marie-Christine Guillet, Icilio Cavero, Charles Brink

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.04 MB

english, 1995

30

Time-dependent fading of the activation of KATP channels, induced by aprikalim and nucleotides, in excised membrane patches from cardiac myocytes

Dominique Thuringer, Icilio Cavero, Edouard Coraboeuf

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.92 MB

english, 1995

31

The effect of (−)-Δ9-trans-tetrahydrocannabinol on myocardial contractility and venous return in anesthetized dogs

Icilio Cavero, Mustafa F. Lokhandwala, Joseph P. Buckley, Bhagavan S. Jandhyala

Journal:

European Journal of Pharmacology

Year:

1974

Language:

english

File:

PDF, 623 KB

english, 1974

32

Parasympatholytic activity of (-)-Δ9-trans- Tetrahydrocannabinol in mongrel dogs

Icilio Cavero, Joseph P. Buckley, Bhagavan S. Jandhyala

Journal:

European Journal of Pharmacology

Year:

1972

Language:

english

File:

PDF, 214 KB

english, 1972

33

Effects of prolonged hydrochlorothiazide administration on neurogenic tone in the hind limb vasculature

Bhagavan S. Jandhyala, Icilio Cavero, Joseph P. Buckley

Journal:

European Journal of Pharmacology

Year:

1972

Language:

english

File:

PDF, 536 KB

english, 1972

34

Studies on the bradycardia induced by (−)-Δ9-trans-tetrahydrocannabinol in anesthetized dogs

Icilio Cavero, Thomas Solomon, Joseph P. Buckley, Bhagavan S. Jandhyala

Journal:

European Journal of Pharmacology

Year:

1973

Language:

english

File:

PDF, 521 KB

english, 1973

35

Hemodynamic and myocardial effects of (−)-Δ9-trans-tetrahydrocannabinol in anesthetized dogs

Icilio Cavero, Joseph P. Buckley, Bhagavan S. Jandhyala

Journal:

European Journal of Pharmacology

Year:

1973

Language:

english

File:

PDF, 579 KB

english, 1973

36

Analysis of cardiac chronotropic responses to some autonomic blocking agents in conscious trained dogs

Icilio Cavero, Hans Riggenbach, Michael Wall, Marcel Gerold

Journal:

European Journal of Pharmacology

Year:

1976

Language:

english

File:

PDF, 796 KB

english, 1976

37

Time-course effects of oral guanethidine administration on cardiovascular and autonomic effects on dogs

Bhagavan S. Jandhyala, Icilio Cavero, Joseph P. Buckley

Journal:

European Journal of Pharmacology

Year:

1976

Language:

english

File:

PDF, 892 KB

english, 1976

38

Vascular β-adrenoceptor stimulating properties of phenylphrine

Françoise Lefèvre, Simone Fénard, Icilio Cavero

Journal:

European Journal of Pharmacology

Year:

1977

Language:

english

File:

PDF, 294 KB

english, 1977

39

Studies on the mechanism of the vasodilator effects of prazosin in dogs and rabbits

Icilio Cavero, Simone Fenard, Roberto Gomeni, Françoise Lefevre, Alan G. Roach

Journal:

European Journal of Pharmacology

Year:

1978

Language:

english

File:

PDF, 936 KB

english, 1978

40

The blood pressure lowering effects of intravenous versus intracerebroventricular prazosin in anaesthetised cats

Alan G. Roach, Roberto Gomeni, Mervyn Mitchard, Jean-Paul Nicolas, Icilio Cavero

Journal:

European Journal of Pharmacology

Year:

1978

Language:

english

File:

PDF, 628 KB

english, 1978

41

“Calcium antagonists”: A class of drugs with a bright future. Part II. Determination of basic pharmacological properties

Michael Spedding, Icilio Cavero

Journal:

Year:

1984

Language:

english

File:

PDF, 962 KB

english, 1984

42

Endothelin - a new family of endothelium-derived peptides with widespread biological properties

Anne-Charlotte Le Monnier de Gouville, Howard L. Lippton, Icilio Cavero, Warren R. Summer, Albert L. Hyman

Journal:

Year:

1989

Language:

english

File:

PDF, 1.27 MB

english, 1989

43

The pharmacology of prazosin, a novel antihypertensive agent

Icilio Cavero, Alan G. Roach

Journal:

Year:

1980

Language:

english

File:

PDF, 1.06 MB

english, 1980

44

Peripheral dopamine receptors, potential targets for a new class of antihypertensive agents: Part II: Sites and mechanisms of action of dopamine receptor agonists

Icilio Cavero, Roy Massingham, Françoise Lefèvre-Borg

Journal:

Year:

1982

Language:

english

File:

PDF, 625 KB

english, 1982

45

Peripheral dopamine receptors, potential targets for a new class of antihypertensive agents: Part I: Subclassification and functional description

Icilio Cavero, Roy Massingham, Françoise Lefèvre-Borg

Journal:

Year:

1982

Language:

english

File:

PDF, 529 KB

english, 1982

46

“Calcium antagonists”: A class of drugs with a bright future. Part I. Cellular calcium homeostasis and calcium as a coupling messenger

Icilio Cavero, Michael Spedding

Journal:

Year:

1983

Language:

english

File:

PDF, 680 KB

english, 1983

47

K+ channel openers and ‘natural’ cardioprotection

Denis Escande, Icilio Cavero

Journal:

Trends in Pharmacological Sciences

Year:

1992

Language:

english

File:

PDF, 561 KB

english, 1992

48

Evidence for NK-1 receptor subtypes from in vivo bronchopulmonary and cardiovascular studies

Anne Floch, Nicole Massa, Chantal Thiry, Icilio Cavero

Journal:

Regulatory Peptides

Year:

1993

Language:

english

File:

PDF, 116 KB

english, 1993

49

Evaluation of the Rabbit Purkinje Fibre Assay as an in vitro Tool for Assessing the Risk of Drug-Induced Torsades de Pointes in Humans

Marion Aubert, Rolf Osterwalder, Björn Wagner, Isabelle Parrilla, Icilio Cavero, Lucette Doessegger, Dr Eric A. Ertel

Journal:

Year:

2006

Language:

english

File:

PDF, 274 KB

english, 2006

50

Drug discovery paradigms: past, present, future – a centennial symposium of the American Society for Pharmacology and Experimental Therapeutics

Cavero, Icilio, Kaplan, Harvey R

Journal:

Expert Opinion on Drug Discovery

Year:

2008

Language:

english

File:

PDF, 251 KB

english, 2008

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